4/1/2024 0 Comments Allplan 2015 full mega![]() ![]() GABA levels more rapidly declined with advancing age in the schizophrenia compared with the control group. This is the largest MRS study of GABA in schizophrenia and the first to examine GABA without macromolecule contamination, a potentially significant issue in previous studies. GABA levels were specifically related to working memory but not processing speed performance, functional capacity, or positive or negative symptom severity. Age strongly predicted GABA levels in the schizophrenia group accounting for 42% of the variance, but the effect of age was less in the control group accounting for 5.7% of the variance. ![]() GABA levels were significantly lower in the older participants with schizophrenia ( n=31) compared with the older control ( n=37) group ( P=0.003) but not between the younger control ( n=40) and schizophrenia ( n=29) groups ( P=0.994). Patients were evaluated for psychopathology and all participants completed neuropsychological tests of working memory, processing speed and functional capacity. For detection of GABA, spectra were acquired from the medial frontal/anterior cingulate cortex using a macromolecule-suppressed MEGA-PRESS sequence. One-hundred forty-five participants completed this study. Proton magnetic resonance spectroscopy (MRS) was used to test the hypothesis that older participants with schizophrenia have lower anterior cingulate GABA levels compared with older control participants. Gamma-butyric acid (GABA) dysfunction has been implicated in the pathophysiology of schizophrenia and its cognitive deficits. ![]()
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